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Studies on the synthesis of stemona alkaloids stereoselective preparation of the hydroindole ring system by oxidative cyclization of tyrosine

Studies on the synthesis of stemona alkaloids stereoselective preparation of the hydroindole ring system by oxidative cyclization of tyrosine

Tetrahedron Letters 33(38): 5477-5480

The core hydroindole ring system of the Stemona alkaloids was prepared by oxidation of tyrosine with a hypervalent iodine reagent followed by a diastereotopic group-selective intramolecular conjugate addition. Further transformations illustrate the versatility of this highly functionalized hydroindolenone for alkaloid synthesis.

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Accession: 007836658

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DOI: 10.1016/s0040-4039(00)61121-8

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