Suppression of late phase enhanced vascular permeability in rats by selective depletion of neutrophils with a monoclonal antibody

Sekiya, S.; Yamashita, T.; Sendo, F.

Journal of Leukocyte Biology 48(3): 258-265

1990


ISSN/ISBN: 0741-5400
PMID: 2391449
DOI: 10.1002/jlb.48.3.258
Accession: 007846952

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Abstract
We investigated the role of neutrophils in increased vascular permeability be a selective reduction of neutrophils using a monoclonal antibody, RP-3. An intraperitoneal injection of RP-3 not only selectively depleted peripheral blood neutrophils, but prevented the neutrophil infiltration to the tissues. Proteose peptone, zymosan, and BCG induced three different types of inflammatory edema, showing the early phase only, early plus late phase, and the late phase only, respectively. Only the last phase response of zymosan and BCG was inhibited by a depletion of neutrophils by RP-3, though the early phase response induced by proteose peptone and zymosan was not affected. Reconstitution of neutrophil-depleted rats by in situ injection of these cells restored the inflammatory edema induced by BCG, depending upon the number of neutrophils injected.

Suppression of late phase enhanced vascular permeability in rats by selective depletion of neutrophils with a monoclonal antibody