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Chapter 7,848

Suppression of release of microfilariae in vitro from Setaria cervi (Nematoda: Filariodeae) by chlorpromazine

Tekwani, B.L.; Tripathi, L.M.; Shukla, O.P.; Ghatak, S.

Journal of Parasitology 74(5): 893-895

1988


ISSN/ISBN: 0022-3395
PMID: 3138401
DOI: 10.2307/3282277
Accession: 007847130

Chlorpromazine (CPZ) caused suppression in release of microfilariae in vitro from Setaria cervi at 10(-5) M concentration. The inhibitory effect of CPZ was further stimulated by Ca2+ (2 mM), whereas addition of EGTA (2 mM) resulted in partial reversal. Addition of dopamine (1 mM) along with CPZ (10(-5) M) caused similar inhibition as was observed in the presence of CPZ (10(-5) M) alone. CPZ did not effect in vitro oxygen uptake by worm homogenates up to 0.5 mM concentration. The results indicate the Ca2+/calmodulin-dependent anthelmintic action of CPZ on S. cervi.

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