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The Drosophila gene coding for the alpha subunit of a stimulatory G protein is preferentially expressed in the nervous system


The Drosophila gene coding for the alpha subunit of a stimulatory G protein is preferentially expressed in the nervous system



Proceedings of the National Academy of Sciences of the United States of America 86(11): 4321-4325



ISSN/ISBN: 0027-8424

PMID: 2498884

DOI: 10.1073/pnas.86.11.4321

In mammals, the .alpha. subunit of the stimulatory guanine nucleotide-binding protein (Gs.alpha.) functions to couple a variety of extracellular membrane receptors to adenylate cyclase. Activation of Gs.alpha. results in the stimulation of adenylate cyclase and an increase in the second messenger cAMP. A 1.7-kilobase cDNA has been identified and characterized from Drosophila that codes for a protein 71% identical to bovine Gs.alpha. The similarity is most striking in the regions thought to be responsible for the interactions with receptors and effectors, suggesting that the basic components of this signal-transduction pathway have been conserved through evolution. RNA blot hybridization and DNA sequence analysis suggest that a single transcript, expressed predominantly in the head, is present in Drosophila. In situ hybridization studies indicate that the Drosophila Gs.alpha. transcript is localized primarily in the cells of the central nervous system and in the eyes.

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Accession: 007884284

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