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The effects of bfgf igd i and tgf beta on rmo skeletal muscle cell proliferation and differentiation



The effects of bfgf igd i and tgf beta on rmo skeletal muscle cell proliferation and differentiation



Experimental Cell Research 187(2): 250-254



A new skeletal muscle cell line, rat myoblast .omega. or RMo, has been characterized with regard to the effects of three growth factors: basic fibroblast growth factor (bFGF), insulin-like growth factor I (IGF-I), and transforming growth factor .beta. (TFG-.beta.). Results indicate a differential response of these factors on both cell proliferation and differentiation. Exposure to bFGF and IGF-I stimulate proliferation, while TGF-.beta. has no effect on cell number. RMo cell differentiation, as indicated by skeletal myosin synthesis, is enhanced by IGF-I, whereas both bFGF and TGF-.beta. suppress differentiation. These responses are in agreement with the effects of bFGF, IGF-I, and TGF-.beta. on myogenic cells cultured from fetal and postnatal muscle, thereby suggesting that RMo cells can serve as a model system for the study of growth factor effects on skeletal muscle cells.

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Accession: 007894659

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PMID: 2180733



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