+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The presence of a dna binding complex correlates with e b class ii mhc gene expression

, : The presence of a dna binding complex correlates with e b class ii mhc gene expression. EMBO (European Molecular Biology Organization) Journal 9(5): 1543-1550

The class II major histocompatibility complex (MHC, Ia) antigens are a family of membrane proteins whose expression is strictly regulated. They have a limited tissue distribution and their expression is regulated both developmentally and in response to external stimuli. Here we report the identification of a DNA binding protein complex (termed complex A) within the murine E.beta. MHC gene, which is restricted to cells that express Ia antigens. Complex A binding activity is developmentally regulated in cells of the B lineage in accordance with class II expression and is responsive to two different Ia-inducing lymphokines interferon-.gamma. in macrophages and interleukin-4 in pre-B cells. The DNA target sequence in complex A includes three previously defined transcriptional motifs W, X and Y, and acts as a cis-acting transcription element. Complex A is present both in cells that are constitutive for class II MHC expression and in cells that have been induced for class II MHC expression. These results suggest that complex A may play a critical role in the regulation of class II MHC gene expression.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 007924525

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Werwath, Joern; Arfmann, Hans-Adolf; Pieper, Dietmar, H.; Timmis, Kenneth, N.; Wittich, Rolf-Michael, 1998: Biochemical and genetic characterization of a gentisate 1,2-dioxygenase from Sphingomonas sp. strain RW5. The biochemical and genetic characterization of a gentisate 1,2-dioxygenase (GDO) from Sphingomonas sp. strain RW5 are described. Cloning and sequencing of a DNA fragment containing the GDO gene gtdA revealed a gene product of 350 amino acids tha...

De Guiran G., 1973: Quantitative and qualitative aspect of a nematode inoculum in the soil. Annales de Phytopathologie 5(3): 315

Graham, Laurel, 2005: How Do I Keep Up with Research in Food and Nutrition?. Journal of the American Dietetic Association 105(5): 5

Reichelt, Olaf; Hochmuth, Albrecht; Wunderlich, Heiko; Kaiser, Werner Alois; Schubert, Joerg, 2000: Pulse inversion harmonic ultrasound imaging for detecting small renal cell carcinoma. Journal of Urology 163(4 Suppl ): 315, April

Webster, L.; Campbell, L. A., 2002: Chlorobiphenyl contaminants at Pladda and Garroch Head in the Firth of Clyde following the cessation of sewage sludge dumping. Sewage sludge dumping at Garroch Head in the Firth of Clyde, Scotland, UK ceased on 31 December 1998. Eighteen of the 209 chlorinated biphenyls (CBs) were measured in plaice, (Pleuronectes platessa), livers, collected between 1999 and 2000, from t...

Razafindraibe, H.; Montagnon, D.; Rumpler, Y., 1998: Classification and phylogeny of Indriidae by comparison of highly repeated DNA band patterns. Folia Primatologica 69(1): 46, Jan -Feb

Boyles, Sl; Koch, Kb, 1992: Feeding barley to swine. NDSU Extension Service: ication: 19-26

Rioni Volpato M.; Chiericato G.M., 1972: Effects of steamed rolled maize m ensiled ear corn m and dry ear corn m on performance of young bulls. Alimentazione Animale 16(2): 25-36

Davis E. N.; Bastas C., 1978: Petrology and geochemistry of the metamorphic system of Santorini Island. Pages 61-79 1978

Opheim, M., 1975: Nye lokaliteter for norsk Lepidoptera samt sjeldnere funn 8. Atalanta(rveg(4): 111-119.