The release of zinc and amino acids into the hippocampus by intracranial perfusion of kainic acid studies using brain microdialysis and timm staining
Fukunishi, I.; Murakami, T.; Negi, T.; Hosokawa, K.
Neurosciences 16(4): 613-622
The release of zinc and amino acids into the extracellular space of the hippocampus (HIPP) was examined by intracranial perfusion of kainic acid (KA) using brain microdialysis and Timm staining. KA induced a significant increase of the extracellular zinc and glutamate and no changes of the extracellular .gamma.-aminobutyric acid (GABA), aspartate and taurine in the HIPP. A markedly decreased Timm staining in HIPP was observed ranging from CA1 to CA3. These results suggest that the seizure manifestation on an EEG by KA administration is associated with the release of zinc and glutamate into the HIPP extracellular space.