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The synthesis and conformation in solution of cyclo l pro l leu l gln thz gly thz l val dolastatin 3

Holzapfel, C.W.; Van Zyl, W.J.; Roos, M.

Tetrahedron 46(2): 649-660

1990


ISSN/ISBN: 0040-4020
Accession: 007939051

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Dolastatin 3, a unique cyclic peptide, was synthesised in high yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force field calculations, and is characterised by three intramolecular hydrogen bonds.

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