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The tubulin gene cluster of trypanosoma brucei starts with an intact beta gene and ends with a truncated beta gene interrupted by retrotransposon like sequence



The tubulin gene cluster of trypanosoma brucei starts with an intact beta gene and ends with a truncated beta gene interrupted by retrotransposon like sequence



Gene (Amsterdam) 80(1): 177-184



In Trypanosoma brucei the genes coding for .alpha.- and .beta.-tubulin are arranged in a single cluster comprising about ten alternating .alpha. and .beta. genes. The cluster starts at its 5' end with an intact .beta. gene. In this area, a 1.1-kb segment upstream of the mini-exon addition site has been sequenced. Several potential transcription signals were seen The 3' end of the cluster terminates in the middle of a .beta. gene, making it an inactive truncated pseudogene. The adjoining 1.7-kb sequence shows a high degree of similarity with a retrotransposon-like (RTnL) element previously characterized elsewhere in the trypanosome genome. This is the first report of an RTnL element interrupting a protein-coding gene of T. brucei.

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Accession: 007941236

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PMID: 2551783


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