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Thermodynamics of partitioning in the n octanol water system of some beta blockers



Thermodynamics of partitioning in the n octanol water system of some beta blockers



International Journal of Pharmaceutics 63(1): 73-76



It is possible to obtain by thermometric titrimetry the water/n-octanol transfer enthalpy of a series of .beta.-blockers. The transfer entropy can be assessed by combining these results with the corresponding values of the partition coefficients determined independently. The results obtained are discussed according to the pharmacological properties of these substances.

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Accession: 007947813

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