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Thiophene isosteres synthesis and biological evaluation of 3 substituted derivatives of 4 phenyl 2 thioxo benzo 4 5 thieno 2 3 d pyrimidine



Thiophene isosteres synthesis and biological evaluation of 3 substituted derivatives of 4 phenyl 2 thioxo benzo 4 5 thieno 2 3 d pyrimidine



European Journal of Medicinal Chemistry 26(3): 323-330



As an extension of a previous work, in which a series of 4-phenyl-2-thioxo-benzo[4,5]thieno[2,3-d]pyrimidines were synthesized, a new series of 3-amino derivatives of this ring system has been prepared. The products obtained together with those reported in the previous paper, were tested for analgesic, antipyretic and anti-inflammatory activities as well as for acute toxicity. Since these compounds could be useful for the treatment of neoplasms, their cytostatic activity was also investigated.

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Accession: 007948674

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DOI: 10.1016/0223-5234(91)90065-u


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