EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Treatment of experimental zygomycosis in guinea pigs with azoles and with amphotericin B


Treatment of experimental zygomycosis in guinea pigs with azoles and with amphotericin B



ChemoTherapy 35(4): 267-272



ISSN/ISBN: 0009-3157

PMID: 2548818

DOI: 10.1159/000238681

Nonpredisposed Albino guinea pigs were infected intravenously with Rhizopus microsporus var. rhizopodiformis or with Rhizopus oryzae. Both strains were highly pathogenic. They killed all control animals between days 4 and 7 and between days 5 and 9 after infection, respectively. All animals presented invasion of almost all internal organs and skin eruptions developing into ulcers. Oral treatment with ketoconazole, itraconazole, fluconazole or saperconazole was inefficacious. Parenteral treatment with amphotericin B prolonged survival and was life-saving in 9 out of 12 guinea pigs infected with Rh. microsporus var. rhizopodiformis and in 5 out of 12 infected with Rh. oryzae. More active therapy is needed.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007966286

Download citation: RISBibTeXText

Related references

Experimental zygomycosis due to Rhizopus spp. infection by various routes in guinea-pigs, rats and mice. Mycoses 31(11): 563-578, 1988

Effect of tissue invasion and treatment with itraconazole or amphotericin B on galactomannan levels in plasma of guinea pigs with experimental invasive aspergillosis. Journal of Medical and Veterinary Mycology 31(4): 315-324, 1993

Activities of the modified polyene N-D-ornithyl amphotericin methyl ester and the azoles ICI 153066, Bay n 7133, and Bay l 9139 compared with those of amphotericin B and ketoconazole in the therapy of experimental blastomycosis. Antimicrobial Agents and ChemoTherapy 27(3): 363-366, 1985

Complete resolution of pulmonary Rhizopus oryzae infection with itraconazole treatment: more evidence of the utility of azoles for zygomycosis. Mycoses 47(3-4): 159-162, 2004

Interaction between azoles and amphotericin B in the treatment of candidiasis. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 20(4): 1079, 1995

Lipid formulations of amphotericin B as first-line treatment of zygomycosis. Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 15(Suppl): 87-92, 2009

Primary treatment of zygomycosis with liposomal amphotericin B: analysis of 28 cases. Medical Mycology 48(3): 511-517, 2010

Successful treatment of rhinocerebral zygomycosis with a combination of caspofungin and liposomal amphotericin B. Haematologica 90(12 Suppl): Ecr39, 2005

Combination of amphotericin B and azoles in the treatment of filamentous fungal infections Report of 3 cases. Abstracts of the General Meeting of the American Society for Microbiology 96: 79, 1996

Successful treatment of zygomycosis of the paranasal sinuses with surgical debridement and amphotericin B colloidal dispersion. American Journal of Otolaryngology 14(4): 249-253, 1993

Investigation of experimental dicroceliasis in lambs pigs and guinea pigs part 1 ultrastructural changes in the liver of experimental dicroceliasis in guinea pigs. Izvestiya na Tsentralnata Khelmintologichna Laboratoriya B"lgarska Akademiya na Naukite 16: 128-152, 1973

Hemagglutination phenomenon between tanned erythrocytes and serum of guinea pigs. Effect of chemotherapeutic treatment on tanned erythrocyte-agglutinating activity of serum in experimental tuberculosis of guinea pigs. Japanese Journal of Tuberculosis 13(1): 9-15, 1965

Treatment outcome of invasive mould disease after sequential exposure to azoles and liposomal amphotericin B. Journal of Antimicrobial ChemoTherapy 65(1): 114-117, 2010

Severe cutaneous zygomycosis: evaluation of treatment with high doses of liposomal amphotericin B in a one-year old child. Journal of ChemoTherapy 19(3): 347-349, 2007

Successful treatment of cutaneous zygomycosis with intravenous amphotericin B followed by oral posaconazole in a multivisceral transplant recipient. Transplantation 90(10): 1133-1135, 2010