+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ultrastructural cerebrovascular changes in a model of subarachnoid hemorrhage in baboon based on triple cisternal blood injection



Ultrastructural cerebrovascular changes in a model of subarachnoid hemorrhage in baboon based on triple cisternal blood injection



Surgical Neurology 33(3): 195-201



In a subarachnoid hemorrhage model in the baboon, achieved through three cisternal blood injections with 1-day intervals, the cerebral arteries were dissected out 7 days after the first blood injection for electron microscopy. All the animals showed ultrastructural changes in the cerebral arteries: two with severe, one with moderate, and three with mild alterations in the vessel walls. The most constant findings were seen in the muscle cells of the media layer. Fragmentation of the nuclei was frequently observed together with cytoplasmic vacuoles. Scattered groups or single degenerated muscle cells were also noted. In the intima the changes included rounding of the nuclei along with the appearance of cytoplasmic vacuoles. Desquamation or flattening of the endothelium and loss of tight junctions were encountered in some vessel areas. Degenerating mitochondria were a common finding.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007978617

Download citation: RISBibTeXText

PMID: 2315830

DOI: 10.1016/0090-3019(90)90184-q


Related references

Computer controlled cisternal infusion of blood, a new small animal model of subarachnoid hemorrhage. Marmarou, A, Bullock, R, Avezaat, C, Baethmann, A, Becker, D, Brock, M, Hoff, J, Nagai, H, Reulen, H -J Acta Neurochirurgica Supplement; Intracranial pressure and neuromonitoring in brain injury: 390, 1998

Improved outcome in high-grade aneurysmal subarachnoid hemorrhage by enhancement of endogenous clearance of cisternal blood clots: a prospective study that demonstrates the role of lamina terminalis fenestration combined with modern microsurgical cisternal blood evacuation. Minimally Invasive Neurosurgery 50(6): 355-362, 2008

Combined cisternal drainage and intrathecal urokinase injection therapy for prevention of vasospasm in patients with aneurysmal subarachnoid hemorrhage. Neurologia Medico-Chirurgica 35(10): 732-736, 1995

Cisternal talc injection can induce a delayed and prolonged basilar arterial constriction resembling vasospasm after subarachnoid hemorrhage in dog. Canadian Journal of Neurological Sciences 20(Suppl. 1): S20, 1993

Interobserver variability of cisternal blood on CT after aneurysmal subarachnoid hemorrhage. Neurology 54(11): 2156-2158, 2000

Distribution of cisternal blood in patients with acute hydrocephalus after subarachnoid hemorrhage. Annals of Neurology 31(4): 374-378, 1992

The single and double blood injection rabbit subarachnoid hemorrhage model. Translational Stroke Research 6(1): 88-97, 2015

Rapid spontaneous diminution of cisternal blood on computed tomography in patients with subarachnoid hemorrhage. Surgical Neurology 44(4): 356-364, 1995

Prevention of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage by intraoperative cisternal fibrinolysis using tissue-type plasminogen activator combined with continuous cisternal drainage. Neurologia Medico-Chirurgica 44(11): 569-75; Discussion 576-7, 2004

Double cisterna magna blood injection model of experimental subarachnoid hemorrhage in dogs. Translational Stroke Research 5(6): 647-652, 2014

Effect of cisternal papaverine on cerebral blood flow in patients with subarachnoid hemorrhage--three case reports. Neurologia Medico-Chirurgica 37(1): 49-54, 1997

Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone. Neurosurgery 66(1): 158-64; Discussion 164, 2010

Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: The fisher scale revisited. Stroke 32(9): 2012-2020, 2001

Experimental subarachnoid hemorrhage 1. a new approach to subarachnoid blood injection in cats. Acta Neurochirurgica 62(3-4): 171-176, 1982