Ultrastructural observation of atrial specific granules in heart muscle cells of normal and some experimental conditions in several vertebrate animals

Shimura, Y.; Watari, N.; Mabuchi, Y.; Hotta, Y.

Japanese Journal of Clinical Electron Microscopy 22(1): 111-126


Accession: 007979461

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In the heart muscle cells, especially in atrial heart muscle cells, some specific granules are observable in certain animals including human in normal and experimental conditions. De Bold et al. (1979) indicated that the contents of such specific granules worked to regulate the fluid volume and sodium content in animals bodies. Then, Matsuo et al. (1984) postulated the formula of the substances within specific granules, and named it atrial natriuretic peptide (ANP). In the present experiment, we analyzed comparatively and immunoelectron microscopically the nature and function of ANP-containing specific granules of certain animals including rats, snake (Elaphe climacophora), frog (adult and tadpole of Xenopus laevis), and some fishes (carp, flatfish, saurel and yellow-tail). Some SD rats were used for the experiments in which some chemicals or medicines were administered including isoproterenol, reserpine, furosemide and physiological saline. Some animals were maintained without drinking water for 3 days, and we observed the morphological changes of the atrial heart muscle cells, especially the cell organelles and the specific granules.