EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

4-Hydroxyandrostenedione: A new treatment for postmenopausal patients with breast cancer


, : 4-Hydroxyandrostenedione: A new treatment for postmenopausal patients with breast cancer. European Journal of Cancer 28A(12): 1941-1945

We have evaluated 4-hydroxyandrostenedione, a specific inhibitor of aromatase, as treatment for breast cancer in a phase I dose-ranging study and a phase II study of the best-tolerated dose. 168 postmenopausal patients with locally advanced and metastatic breast cancer were treated intramuscularly. 19% of patients attained a complete or partial response but 26% of those who completed at least 4 weeks treatment responded. Side-effects were least in the group receiving 250 mg every 2 weeks. 13% of patients experienced local discomfort due to the injection and 5% had other side-effects. Serum oestradiol fell to 42.4 and 26.5% of baseline at 7 days after the start of treatment with the 250 mg and 500 mg dose, respectively. We conclude that 4-hydroxyandrostenedione at 250 mg every 2 weeks is a safe and effective form of treatment for postmenopausal patients with metastatic breast cancer.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 008016584

DOI: 10.1016/0959-8049(92)90232-Q

PDF Full Text: 4-Hydroxyandrostenedione: A new treatment for postmenopausal patients with breast cancer


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Law, M.D.; Stein, R.E., 1993: Late infection in healed fractures after open reduction and internal fixation. Nine patients with normal fracture healing after open reduction and internal fixation presented with late infection 15 months to 19 years after injury. Eight of the nine patients had a history of pain at the fracture site for 3 weeks or longer. El...

George, P.; Rossey, G.; Depoortere, H.; Mompon, B.; Allen, J.; Wick, A., 1991: Imidazopyridines: towards novel hypnotic and anxiolytic drugs. Farmaco 46(1 Suppl): 277-288

Hohagen, F.; Kaeppler, C.; Riemann, D.; Weyerer, S.; Berger, M., 1994: Unrealistic expectation concerning sleep quality in elderly patients Results of a study in general practice. Journal of Sleep Research 3(SUPPL 1): 108

Orme G.R.; Salama M., 1990: Reef growth and siliciclastic sedimentation under the influence of late Quaternary sea level changes; an example from the Great Barrier Reef, Australia. International Sedimentological Congress 13: 407

Caillere, L., 1977: The detection of the preys in predatory insects illustrated by a comparative study in two Odonata larvae: Calopteryx splendens (Zygoptera) and Cordulegaster boltoni (Anisoptera). Comportement des Insectes et Milieu Trophique: 65 227-239

Avino, A.J.; Oldenburg, W.A.; Gloviczki, P.; Miller, V.M.; Burgart, L.J.; Atkinson, E.J., 1995: Inferior mesenteric venous sampling to detect colonic ischemia: a comparison with laser Doppler flowmetry and photoplethysmography. Purpose: No single method has been identified that accurately and reliably detects patients with impending bowel infarction during aortic reconstruction. Serial sampling of blood gas from the inferior mesenteric vein (IMV) for detecting colonic is...

Chiba, J.; Takeshima, S.; Mishima, K.; Maeda, H.; Nanai, Y.; Mizuno, K.; Inouye, M., 2007: Artificial DNAs based on alkynyl C-nucleosides as a superior scaffold for homo- and heteroexcimer emissions. DNA-like fluorescent oligomers composed of alkynyl beta-D-ribofuranosides bearing pyrene, perylene, and anthracene as a fluorophore were synthesized by solid-phase DNA synthesis. The fluorescent oligomers possess the defined number and order of th...

Kawamura, K.; Sato, N.; Fukuda, J.; Kodama, H.; Kumagai, J.; Tanikawa, H.; Murata, M.; Tanaka, T., 2003: The role of leptin during the development of mouse preimplantation embryos. Leptin is known to regulate diverse reproductive functions, and recent studies have implicated involvement of leptin in the early mouse embryo development. The aim of the present study was to investigate the expression of leptin and its functional...

Arcioni, S.; Falcinelli, M.; Francia, U.; Lorenzetti, F.; Negri, V.; Veronesi, F., 1985: Qualitative evaluation of spontaneous forage legumes growing in central Italy. Natural populations belonging to 13 different species of annual, biennial and perennial forage legumes were evaluated at Perugia, Italy, for forage quality in 1983 and 1984. Of the annual legumes, Medicago arabica, M. orbicularis and Trifolium sub...

Kudva, Neema, 2008: Teaching Planning, Constructing Theory. Planning Theory & Practice 9(3): 363-376