+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

4-Hydroxyandrostenedione: A new treatment for postmenopausal patients with breast cancer

, : 4-Hydroxyandrostenedione: A new treatment for postmenopausal patients with breast cancer. European Journal of Cancer 28A(12): 1941-1945

We have evaluated 4-hydroxyandrostenedione, a specific inhibitor of aromatase, as treatment for breast cancer in a phase I dose-ranging study and a phase II study of the best-tolerated dose. 168 postmenopausal patients with locally advanced and metastatic breast cancer were treated intramuscularly. 19% of patients attained a complete or partial response but 26% of those who completed at least 4 weeks treatment responded. Side-effects were least in the group receiving 250 mg every 2 weeks. 13% of patients experienced local discomfort due to the injection and 5% had other side-effects. Serum oestradiol fell to 42.4 and 26.5% of baseline at 7 days after the start of treatment with the 250 mg and 500 mg dose, respectively. We conclude that 4-hydroxyandrostenedione at 250 mg every 2 weeks is a safe and effective form of treatment for postmenopausal patients with metastatic breast cancer.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 008016584

PMID: 1419285

DOI: 10.1016/0959-8049(92)90232-Q

Download PDF Full Text: 4-Hydroxyandrostenedione: A new treatment for postmenopausal patients with breast cancer

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Gersemann, M.; Wehkamp, J.; Stange, E.F., 2012: Innate immune dysfunction in inflammatory bowel disease. The pathogenetic mechanisms that cause the two types of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are still under investigation. Nevertheless, there is broad agreement that luminal microbes are of par...

Musch, E.; Malek, M.; Chrissafidou, A., 2003: Amifostine plus erythropoietin in a patient with low-risk myelodysplastic syndrome. Increasingly, the therapeutic use of hematopoietic growth factors and immunomodulatory agents is under investigation in patients with low-risk myelodysplastic syndrome (MDS). Studies on amifostine therapy-alone or in combination with erythropoieti...

Kumar, K.Jagadish.; Manjunath, V.G.; Shailashree, M.; Girish, G.N., 2013: Coinfection with dengue and chikungunya--a case report. Dengue fever outbreaks are reported from India since last 10 years. Since 2005, chikungunya is also causing massive outbreaks in India and other parts of Asia. Both viruses are transmitted by aedes genus and both viruses can re-emerge in many regi...

Kersten, W., 1980: How and when is immunotherapy for pollen allergy carried out?. Hyposensitization with semi-depot extracts was effective in 164 of 201 (81,4%) grass pollen sensitive patients. In 54,1% the results were very good and good. Patients were treated perennially for two years. The success of treatment was evaluated b...

Bjoro T.; Haug E.; Sand O.; Gautvik K.M., 1984: Vasoactive intestinal peptide causes a calcium dependent stimulation of prolactin secretion without altering electrophysiological membrane properties in gh 4c 1 cells. Acta Physiologica Scandinavica 121(3): 8A

Northrup, W. F.IIi, 1997: Apparatus and method for reducing and stabilizing the circumference of a vascular structure. Official Gazette of the United States Patent & Trademark Office Patents 1194(2): 1068, Jan 14

Fuggetta, M.P.; Tricarico, M.; Starace, G.; Pepponi, R.; Bonmassar, E., 1998: Interferons antagonize gamma-ray-induced depression of natural immunity. Purpose: The aim of this study was to determine the inhibitory effects of in vitro radiation on the number and function of natural killer (NK) cells and to investigate the capability of interferons (IFNs) to restore the activity of NK, depressed b...

Haxton, T., J.; Findlay,, 2008: Meta-analysis of the impacts of water management on aquatic communities. Systematic meta-analyses were conducted on the ecological impacts of water management, including effects of (i) dewatering on macroinvertebrates, (ii) a hypolimnetic release on downstream aquatic fish and macro invertebrate communities, and (iii)...

Finsterer, J., 2007: Pancreatitis as a manifestation of mitochondrial disorder. Genetic information is used increasingly in health care. Some experts have argued that genetic information is qualitatively different from other medical information and, therefore, raises unique social issues. This view, called "genetic excep...

He, G-Fang.; Shi, Z-Qiang., 2010: 2-(1H-1,2,3-Benzotriazol-1-yl)-N'-(2-chloro-benzyl-idene)acetohydrazide. In the title compound, C(15)H(12)ClN(5)O, the mean planes of the benzotriazole and chloro-phenyl fragments form a dihedral angle of 70.8 (1)°. In the crystal, mol-ecules are linked into infinite chains along the a axis by N-H⋯O hydrogen bonds...