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A facile synthesis of benzyl 2-amino-3-azido-4-O-p-methoxybenzyl-6-O-benzyl-2,3-dideoxy-alpha-D-glucopyranoside: A key intermediate in the information of a didemnin B analog



A facile synthesis of benzyl 2-amino-3-azido-4-O-p-methoxybenzyl-6-O-benzyl-2,3-dideoxy-alpha-D-glucopyranoside: A key intermediate in the information of a didemnin B analog



Journal of Carbohydrate Chemistry 15(3): 371-381



Although the deprotection of amides by hydrazinolysis is a well established method in carbohydrate chemistry, this reaction is dependent upon the nearby substituents. In our facile synthesis of intermediate benzyl 2-amino-3-azido-4-O-p-methoxybenzyl-6-O-benzyl2,3-dideoxy-alpha-D-glucopyranoside (3), we found that the use of trifluoroacetamides provided a more efficient protection strategy.

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