+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A novel protein kinase gene family in Giardia duodenalis

A novel protein kinase gene family in Giardia duodenalis

Gene (amsterdam). 177(1-2): 194

Two protein kinase (PK) genes, gPK1 and gPK2, were cloned from the genome of the ancient protozoan parasite, Giardia duodenalis (Gd). Both gPK genes and their products are highly homologous (85% and 77% identical, respectively). gPK1 and gPK2 contain all the motifs characteristic of PK, but they are not highly homologous to other PK and therefore belong to a novel PK gene family. Northern blot analysis showed that the gPK genes are expressed in vivo. Southern blot analysis indicated that there are other homologous PK genes in the Gd genome. gPK1 and gPK2 are the first full-length PK genes cloned from this primitive eukaryote. The unique amino acid (aa) sequences of gPK1 and gPK2 suggest that they are involved in unique biological functions in Gd.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008061167

Download citation: RISBibTeXText

PMID: 8921866

DOI: 10.1016/0378-1119(96)00300-9

Related references

A new cysteine-rich protein-encoding gene family in Giardia duodenalis. Gene 169(1): 33-38, 1996

Secreted proteins of Giardia duodenalis - characteristic and role in biology of the parasite Bialka wydzielnicze Giardia duodenalis - charakterystyka i rola w biologii pasozyta. Wiadomosci Parazytologiczne, 511: 15-19, 2005

Telomeric organization of a variable and inducible toxin gene family in the ancient eukaryote Giardia duodenalis. Genome Research 7(1): 37-46, 1997

Protein kinase C isoforms from Giardia duodenalis: identification and functional characterization of a beta-like molecule during encystment. Archives of Microbiology 187(1): 55-66, 2006

Cross-species transmission of avian and mammalian Giardia spp: inoculation of chicks, ducklings, budgerigars, mongolian gerbils and neonatal mice with Giardia ardeae, Giardia duodenalis (lamblia), Giardia psittaci and Giardia muris. International Journal of Environmental Health Research, 13: 144-152, 1991

Differentiation of Giardia duodenalis from other Giardia spp. by using polymerase chain reaction and gene probes. Journal of Clinical Microbiology 30(1): 74-78, 1992

A Giardia duodenalis gene encoding a protein with multiple repeats of a toxin homologue. Parasitology 111: 423-431, 1995

The 3' terminal region of a gene encoding a cysteine-rich surface protein in Giardia duodenalis. International Journal for Parasitology 23(6): 785-792, 1993

Identification of Giardia species and Giardia duodenalis assemblages by sequence analysis of the 5.8S rDNA gene and internal transcribed spacers. Parasitology 137(6): 919-925, 2010

Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase. Plos One 10(9): E0136102, 2016

Cloning and restriction enzyme mapping of ribosomal DNA of Giardia duodenalis, Giardia ardeae and Giardia muris. Molecular and Biochemical Parasitology, 462: 275-284, 1991

Structure motility and mechanism of attachment of giardia agilis giardia muris and giardia duodenalis. Molecular & Biochemical Parasitology (SUPPL): 753, 1982

Unique phylogenetic position of Diplomonadida based on the complete small subunit ribosomal RNA sequence of Giardia ardeae, Giardia muris, Giardia duodenalis and Hexamita sp. FASEB (Federation of American Societies for Experimental Biology) Journal 7(1): 223-231, 1993

Population expansion and gene flow in Giardia duodenalis as revealed by triosephosphate isomerase gene. Parasites and Vectors 8: 454, 2016

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. Journal of Chemical Information and Modeling 55(12): 2611-2622, 2016