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A single mutation of the neurokinin-2 (NK2) receptor prevents agonist-induced desensitization. Divergent conformational requirements for NK2 receptor signaling and agonist-induced desensitization in Xenopus oocytes

Nemeth, K.; Chollet, A.

Journal of Biological Chemistry 270(46): 27601-27605

1995

ISSN/ISBN: 0021-9258
PMID: 7499223
Accession: 008077446
Receptor activation and agonist-induced desensitization of the human neurokinin-2 (NK2) receptor expressed in Xenopus oocytes have been investigated. When neurokinin A (NKA) was applied repeatedly at 5-min intervals, the second and subsequent applications gave no responses. This desensitization was not observed with the specific agonists (Lys-3, Gly-8-R-gamma-lactam-Leu-9)NKA(3-10) (GR64349) or (Nle-10)-NKA(4-10).

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