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A study on factors influencing the droplet size in nonionic oil-in-water microemulsions



A study on factors influencing the droplet size in nonionic oil-in-water microemulsions



International Journal Of Pharmaceutics (amsterdam). 88(1-3): 417-422



The droplet size in oil-in-water microemulsions formed from isopropyl myristate (IPM), sorbitol (S), water and either polysorbate (P) 80, 60 or 40 was determined by total intensity light scattering measurements. Data were analyzed using a hard-sphere model to correct for interparticle interactions. Phase studies on systems prepared using P40 have shown an optimum P/S mass ratios of 1:1.5 for microemulsion formation. The droplet size of all microemulsions increased with increasing volume fraction of IPM. At a given IPM content the droplet size was influenced by the structure of the polysorbate, the P/S ratio and the total P+S content. At a constant P/S ratio, the droplet size decreased with change of surfactant in the series P80 gt P60 gt P40. For microemulsions prepared with each polysorbate, change of the P/S ratio in the series 1:3, 1:2.5, 1:2, 1:1.5 caused a progressive decrease of droplet size. An increase of total P + S content from 40 to 45% w/w at a P/S ratio of 1:2.5 caused a decrease of the droplet size in microemulsions prepared with P80.

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Accession: 008080854

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DOI: 10.1016/0378-5173(92)90341-x


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