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A subfraction, derived from a non-protective Leishmania infantum extract, protects Balb/c mice against Leishmania major infection

Rolland, L.; Vijayalakshmi, S.V.M.okambeswaran

Comptes Rendus de l'Academie des Sciences Serie III Sciences de la Vie 316(11): 1342-1349

1993


ISSN/ISBN: 0764-4469
Accession: 008081613

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We report the identification of a subfraction isolated by gel filtration liquid chromatography from a non-protective Leishmania infantum extract, which protects Balb/c mice against Leishmania major infection, in conjunction with a bacterial adjuvant. Protected mice exhibited cell-mediated immunity, as assessed by increased numbers of CD4+ and CD8+ spleen cells, and the production of IFN-gamma, as compared to mice who received only the adjuvant before infection.

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