+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Abnormal signal-averaged electrocardiogram in patients with Duchenne muscular dystrophy: Comparison of time and frequency domain analyses from the signal-averaged electrocardiogram



Abnormal signal-averaged electrocardiogram in patients with Duchenne muscular dystrophy: Comparison of time and frequency domain analyses from the signal-averaged electrocardiogram



Clinical Cardiology 16(10): 723-728



The clinical significance of an abnormal signal-averaged electrocardiogram (SA-ECG) in time- and frequency-domain analyses was assessed in patients with Duchenne muscular dystrophy (DMD). Twenty-four DMD patients and 20 age-matched healthy volunteers were studied. The SA-ECG was recorded by time-domain signal processing using the vector-magnitude method and frequency-domain signal processing using the fast-Fourier transform. Abnormal SA-ECGs were based on comparison with controls and eight abnormal SA-ECGs were detected among 24 DMD patients, seven by frequency-domain analysis and four by time-domain analysis. The end-diastolic left ventricular volume was larger in the patients with abnormal SA-ECG than in those with normal SA-ECG (136 +/- 32 ml vs. 77 +/- 43 ml, p < 0.01). Compared with patients with normal SA-ECGs, the DMD patients with abnormal SA-ECGs had a lower left ventricular (LV) ejection fraction (54 +/- 6 vs. 61 +/- 8%, p < 0.05), as an index of LV contractility, and less LV posterior wall velocity (46 +/- 9 mm/min vs. 62 +/- 16 mm/min, p < 0.01), as an index of LV relaxation. The sensitivity and specificity of frequency-domain analysis for predicting malignant ventricular arrhythmias was 60 and 85%, respectively, compared with 30 and 92%, respectively, for time-domain analysis. The combination of time- and frequency-domain analyses can facilitate identification of DMD patients with ventricular tachyarrhythmias associated with depression of cardiac performance.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008090203

Download citation: RISBibTeXText

PMID: 8222385

DOI: 10.1002/clc.4960161007


Related references

Suitable analyzed signal duration and criteria for abnormal signal-averaged electrocardiogram on frequency-domain analysis in patients with Duchenne's muscular dystrophy. Pediatric Cardiology 17(2): 91-96, 1996

Study of suitable analyzed signal duration and criteria for abnormal signal averaged electrocardiogram on frequency-domain analysis in patients with Duchenne's muscular dystrophy. Kokyu to Junkan. Respiration and Circulation 41(11): 1073-1078, 1993

A novel signal-averaged electrocardiogram and an ambulatory-based signal-averaged electrocardiogram show strong correlations with conventional signal-averaged electrocardiogram in healthy subjects: A validation study. Journal of Electrocardiology 51(6): 1145-1152, 2018

Definition of the best prediction criteria of the time domain signal-averaged electrocardiogram for serious arrhythmic events in the postinfarction period. The Cardiac Arrhythmia Suppression Trial/Signal-Averaged Electrocardiogram (CAST/SAECG) Substudy Investigators. Journal of the American College of Cardiology 25(4): 908-914, 1995

Comparison of the new acceleration spectrum analysis with other time- and frequency-domain analyses of the signal-averaged electrocardiogram. European Heart Journal 19(4): 628-637, 1998

Short-, mid-, and long-term reproducibility of the atrial signal-averaged electrocardiogram in healthy subjects: comparison with the conventional ventricular signal-averaged electrocardiogram. Pacing and Clinical Electrophysiology 23(1): 122-127, 2000

Lack of prognostic significance of abnormal signal-averaged electrocardiogram in time or frequency domain analysis in patients with non-ischaemic dilated cardiomyopathy. European Heart Journal 17(ABSTR SUPPL ): 288, 1996

Comparison of frequency and time domain analysis of signal averaged electrocardiogram in postinfarction patients with and without cardiac death during follow-up. Circulation 96(8 SUPPL ): I652, 10/21/97, 1997

Identification of post infarction patients with ventricular tachycardia comparison of the time domain frequency domain and spectral temporal mapping of the signal averaged electrocardiogram. Clinical Science 82(3): 7P-8P, 1992

Identification of Post Infarction Patients with Ventricular Tachycardia. Comparison of the Time Domain, Frequency Domain, and Spectral Temporal Mapping of the Signal-Averaged Electrocardiogram. Clinical Science 82(S26): 7p.4-8p, 1992

Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis. Journal of the American College of Cardiology 11(5): 1041-1051, 1988

Time and frequency domain analyses of signal-averaged electrocardiogram have different predictive values of inducible sustained ventricular tachycardia in myocardial infarction. Circulation 86(4 SUPPL 1): I524, 1992

Is abnormal signal-averaged electrocardiogram in time or frequency domain analysis an independent predictor of mortality post acute myocardial infarction and what is the optimal time of recording?. European Heart Journal 20(ABSTR SUPPL ): 342, 1999

Comparison of frequency and time domain analysis of the signal averaged electrocardiogram in patients with ventricular tachycardia and coronary artery disease methodologic validation and clinical relevance. Journal of the American College of Cardiology 12(1): 150-158, 1988

Improved predictive ability of signal-averaged electrocardiogram by combined time and frequency domain analysis in patients with ischaemic cardiomyopathy. European Heart Journal 20(ABSTR SUPPL ): 8, 1999