Section 9
Chapter 8,103

Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites

Anderson, M.M.; Chen, J.; Cole, C.N.; Conrad, S.E.

Journal of Virology 70(9): 6304-6313


ISSN/ISBN: 0022-538X
PMID: 8709258
Accession: 008102279

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Infection of quiescent cells with the DNA tumor virus simian virus 40 induces expression of the cellular thymidine kinase (TK) gene a minimum of 10- to 20-fold, and this induction depends upon the viral protein large T antigen (T-Ag).

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