+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Activators of sodium, calcium and potassium channels modulate the cardiac effects of Quinidine in vitro



Activators of sodium, calcium and potassium channels modulate the cardiac effects of Quinidine in vitro



Pharmacology and Toxicology 77(5): 346-351



Quinidine (25.5 mu-mol/l) reduced the beating frequency of isolated right guinea-pig atria, caused a negative inotropic effect in papillary muscles and slightly raised the contractile force of left atria. The functional refractory period of both tissues was prolonged. A 20% increase of the extracellular sodium concentration did not reverse the effects of quinidine. The Na-channel activator BDF 9148 (1 mu-mol/l) and the Ca-channel agonist Bay-K-8644 (0.5 mu-mol/l) further increased the contractile force and caused an additional prolongation of the functional refractory period in quinidine-pretreated atria. Only Bay-K-8644 was able to reverse the negative inotropic effect of quinidine in papillary muscles. The influence of Bay-K-8644 on the contractile force in quinidine-pretreated muscles was not attenuated by lemacalim (3 mu-mol/l), an activator of ATP-dependent potassium channels, but the duration of the functional refractory period was significantly reduced. These results suggest that a combination of a calcium channel activator and a potassium channel opener might be able to improve the treatment of quinidine intoxications.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008102749

Download citation: RISBibTeXText

PMID: 8778748

DOI: 10.1111/j.1600-0773.1995.tb01039.x


Related references

Effects of fluorine-containing opener of ATP-sensitive potassium channels, pinacidil-derivative flocalin, on cardiac voltage-gated sodium and calcium channels. Naunyn-Schmiedeberg's Archives of Pharmacology 385(11): 1095-1102, 2012

Calcium-activated potassium channels modulate action potential duration and calcium transients in cardiac myocytes. Circulation 104(17 Suppl.): II 276-II 277, 2001

Potassium channel activators differentially modulate the effect of sodium channel blockade on cardiac conduction. Acta Physiologica 207(2): 280-289, 2013

Differential effects of membrane perturbants on voltage-activated sodium and calcium channels and calcium-dependent potassium channels. Biophysical Journal 45(1): 132-134, 1984

Voltage-dependent sodium channels and calcium-activated potassium channels in human odontoblasts in vitro. Journal of Endodontics 38(10): 1355-1362, 2012

Effects of protein kinase c activators on cardiac calcium channels. Nature (London) 335(6187): 249-251, 1988

SNC80 and naltrindole modulate voltage-dependent sodium, potassium and calcium channels via a putatively delta opioid receptor-independent mechanism. General Physiology and Biophysics 37(3): 299-307, 2018

In vitro effects of palmityl carnitine on cardiac plasma membrane sodium potassium atpase and sarcoplasmic reticulum calcium atpase and calcium transport. Journal of Biological Chemistry 254(24): 12404-12410, 1979

The ph dependence of the effects of sodium ion potassium ion and ouabain on the atpase activity of sodium iodide treated brain microsomes with magnesium ion manganese ion calcium ion and zinc ion as divalent metal activators. Biochimica Et Biophysica Acta: 103-115, 1972

Effects of dietary sodium depletion on potassium transport in rat distal colon in vitro kinetics of potassium absorption and the regulatory role of potassium secretory channels. Journal of Physiology (Cambridge) 396: 34P, 1988

Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents. Naunyn-Schmiedeberg's Archives of Pharmacology 342(1): 94-99, 1990

Structure function and differentiation of sodium channels calcium channels and calcium dependent potassium channels. Biological Chemistry Hoppe-Seyler 366(4): 330-331, 1985

In corneal epithelium swelling induces quinidine sensitive potassium channels shrinking inhibits quinidine insensitive potassium conductance. Federation Proceedings: 1011, 1986

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias. British Journal of Clinical Pharmacology 69(5): 427-442, 2010

Intercalated cell BK-alpha/beta4 channels modulate sodium and potassium handling during potassium adaptation. Journal of the American Society of Nephrology 21(4): 634-645, 2010