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Additive effects of pituitary adenylate cyclase. Activating polypeptide and growth hormone releasing hormone on the release of growth hormone from cultured bovine anterior pituitary cells



Additive effects of pituitary adenylate cyclase. Activating polypeptide and growth hormone releasing hormone on the release of growth hormone from cultured bovine anterior pituitary cells



Animal Science & Technology 66(4): 330-335



Additive effects of pituitary adenylate cyclase-activating polypeptide (PACAP) with growth hormone releasing hormone (GHRH) on the release of growth hormone (GH) were studied in cultured bovine anterior pituitary cells. The combined stimulatory effects of 10-7 M PACAP and GHRH (10-12, 10-10 or 10-8 M) together on the release of GH were similar to those for either PACAP or GHRH alone. When 10-8 M PACAP and 10-8 M GHRH were added together, the release of GH induced by both peptides was significantly greater than those by either PACAP or GHRH alone (P lt 0.05). When 10-9 M PACAP and 10-8 M GHRH were added together, the release of GH induced by both peptides was significantly greater than those of either PACAP or GHRH alone (P lt 0.05). The additive effects on the release of GH were not observed when PACAP (10-8 M or 10-9 M) was combined with either 10-10 M or 10-12 M GHRH. These findings suggest that PACAP interacts additionally with GHRH in stimulating growth hormone release under limited concentrations of both peptides in cattle.

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Accession: 008110262

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