Section 9
Chapter 8,121

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms

Melendez, A.J.; Gillooly, D.J.; Harnett, M.M.; Allen, J.M.

Proceedings of the National Academy of Sciences of the United States of America 95(5): 2169-2174


ISSN/ISBN: 0027-8424
PMID: 9482857
Accession: 008120955

Phosphoinositide 3-kinases (PI3-kinases) play an important role in the generation of lipid second messengers and the transduction of a myriad of biological responses. Distinct isoforms have been shown to be exclusively activated either by tyrosine kinase-coupled or G protein-coupled receptors.

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