+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Alternation learning in obsessive-compulsive disorder

Alternation learning in obsessive-compulsive disorder

Biological Psychiatry 39(8): 733-738

The Wisconsin Card Sorting Test (WCST) and an alternation learning task were administered to 15 women with obsessive-compulsive disorder (OCD) and 15 age-, sex-, education-, and intelligence-matched healthy controls. OCD patients were significantly slower on the WCST as compared to the controls. Their performance on the alternation learning task was impaired relative to the control group, though this difference was diminished when we used education as a covariate. We found a significant positive correlation between performance on the alternation task and severity of symptoms in the OCD group. Performance of similar alternation tasks is impaired by damage to the orbitofrontal cortex in nonhuman primates. Therefore the data presented support the hypothesis of orbitofrontal cortex dysfunction in OCD.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008132606

Download citation: RISBibTeXText

PMID: 8731461

DOI: 10.1016/0006-3223(95)00179-4

Related references

Orbitofrontal cortex dysfunction in obsessive-compulsive disorder? I. Alternation learning in obsessive-compulsive disorder: Male-female comparisons. European Neuropsychopharmacology 9(5): 407-413, Sept, 1999

Comorbidity of obsessive-compulsive disorder with obsessive-compulsive personality disorder: Does it imply a specific subtype of obsessive-compulsive disorder?. Psychiatry Research 177(1-2): 156-160, 2010

No evidence for object alternation impairment in obsessive-compulsive disorder (OCD). Brain and Cognition 69(1): 176-179, 2008

Further evidence for delayed alternation deficits in obsessive-compulsive disorder. Journal of Nervous and Mental Disease 189(8): 562-564, 2001

Spontaneous alternation an animal model for obsessive compulsive disorder. Society for Neuroscience Abstracts 16(1): 140, 1990

Prevalence of Childhood Obsessive-Compulsive Personality Traits in Adults with Obsessive Compulsive Disorder versus Obsessive Compulsive Personality Disorder. Journal of Obsessive-Compulsive and Related Disorders 4(): 25-29, 2015

Obsessive compulsive phenomena in adult obsessionality, compulsive personality disorder and obsessive compulsive disorder (neurosis). Psychiatric Journal of the University of Ottawa 12(4): 214-221, 1987

Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. Indian Journal of Psychological Medicine 36(3): 326-328, 2014

Complex segregation analysis of obsessive-compulsive disorder in 141 families of eating disorder probands, with and without obsessive-compulsive disorder. American Journal of Medical Genetics 96(3): 384-391, June 12, 2000

Evaluation of reinforced alternation in the T-maze as a putative animal model of obsessive compulsive disorder. Neuropsychopharmacology 23(S2): S36, August, 2000

Object alternation test--is it sensitive enough to detect cognitive dysfunction in obsessive-compulsive disorder?. European Psychiatry 19(7): 441-443, 2004

Perseveration and not strategic deficits underlie delayed alternation impairment in obsessive-compulsive disorder (OCD). Psychiatry Research 170(1): 66-69, 2010

The relationship between obsessive-compulsive personality disorder traits, obsessive-compulsive disorder and excessive exercise in patients with anorexia nervosa: a systematic review. Journal of Eating Disorders 1: 16-16, 2013