+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibodies against enteroviruses in intravenous Ig preparations: Great variation in titres and poor correlation with the incidence of circulating serotypes



Antibodies against enteroviruses in intravenous Ig preparations: Great variation in titres and poor correlation with the incidence of circulating serotypes



Journal of Medical Virology 53(3): 273-276



Antibody titres in immunoglobulin preparations for intravenous use were tested against 24 different enterovirus serotypes and varied between 1:100 and 1:10,000 within a single batch. Differences up to 8-fold were found for homologous titres between two different batches that were prepared 6 years apart. The lowest titre obtained was 1:40. The observed differences within and between the two batches could not be explained by different incidence of serotypes of enteroviruses circulating at the time blood was collected. Differences in titres of up to 18-fold were observed when several strains of the same serotype were tested suggesting that intratypic variation influences antibody titres. It is concluded that immunoglobulin preparations contain antibodies against many enteroviruses, but that titres can be low and cannot be predicted from the incidence of any particular serotype circulating in the community. Because of intratypic variation, selection of a batch for specific treatment should be based on results obtained with the patient's own isolate, and not with a reference strain.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008169653

Download citation: RISBibTeXText

PMID: 9365895

DOI: 10.1002/(sici)1096-9071(199711)53:3<273::aid-jmv16>3.0.co;2-i


Related references

Non-polio enteroviruses serotypes circulating in Nigeria. African Journal of Medicine and Medical Sciences 39 Suppl: 201-208, 2010

Detection of antibodies to various Leptospira serotypes and their titres in horses. Veterinarski Glasnik 38(9/10): 765-769, 1984

Studies on cytopatho-genic avian enteroviruses. II. Influence of age on virus excretion and incidence of certain serotypes in a colony of chicks. Avian Diseases 10: 27-32, 1966

Correlation of Circulating Antibody Titres with Activity of Disease in Pemphigus. Indian Journal of Dermatology Venereology and Leprology 55(4): 224-226, 1989

Studies on the inhibition by hyperimmunization of circulating antibodies. Effects of suppression of variation of antigenlc stimulus at the time of maximal production of circulating antibodies in the hyper-immunized animal. Pathol Et Microbiol [basel] 26(4): 439-454, 1963

Studies on the "inhibition by Hyperimmunization of Circulating Antibodies". Effects of Suppression or Variation of Antigenic Stimulus at the time of Maximal Production of Circulating Antibodies in the Hyperimmunized (Hyperstimulated) Animal. Pathologia et Microbiologia 26: 439-454, 1963

Antibodies against enteroviruses in human serum gamma-globulin preparations Abstract only. Vop Virusol: 498, 1967

Cicatricial pemphigoid: Serial titres of circulating IgG and IgA antibasement membrane antibodies correlate with disease activity. British Journal of Dermatology 140(4): 645-650, 1999

IgG antibody reactive with five serotypes of Streptococcus pneumoniae in commercial intravenous immunoglobulin preparations. Journal of Infectious Diseases 166(1): 38-42, 1992

Correlation between worm burden and the incidence of circulating anodic antigens or antibodies in mice infected with Schistosoma japonicum or Schistosoma mansoni. Kurume Medical Journal 35(1): 13-18, 1988

The incidence of pathogenic serotypes of escherichia coli in preparations of frozen meat. Cadariu, Gh , And B Barhad (Edited By) Activiatea Stintifica A Institutului De Igiena, Bucharesti 1927-1967 (Scientific Session Of The Institute Of Public Health, Bucharest 1927-1967) 457p Editua Medicala: Bucharest, Rumania 381-383, 1968

Very Low Prevalence of Circulating Antibodies Against Common Aav Serotypes in a Population of Cats. Molecular Therapy 23: S182-S183, 2015

Detection and genetic characterization of enteroviruses circulating among wild populations of chimpanzees in Cameroon: relationship with human and simian enteroviruses. Journal of Virology 85(9): 4480-4486, 2011

Incidence and distribution of neutralizing antibodies to porcine enteroviruses in Southern Africa. Journal of the South African Veterinary Association 44(3): 247-250, 1973

Absence of anti hla antibodies ab1 and antiidiotype antibodies ab2 in different preparations of intravenous immunoglobulins. Bollettino Societa Italiana Biologia Sperimentale 66(12): 1193-1200, 1990