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Antibodies to casein kinase II in sera of patients with mixed connective tissue disease: evaluation with recombinant proteins



Antibodies to casein kinase II in sera of patients with mixed connective tissue disease: evaluation with recombinant proteins



Clinical Chemistry 39(12): 2492-2494



In this study we determined the prevalence of autoantibodies against casein kinase II (CKII) in patients positive for anti-70K marker antibodies, which is indicative of mixed connective tissue disease. An anti-CKII ELISA was established with the use of bacterially expressed recombinant CKII proteins. Eight out of 52 anti-70K-positive sera (15%) were positive for anti-CKII antibodies, which recognized preferentially the CKII-alpha subunit. All control sera (n = 52) were anti-CKII negative. Thus, the occurrence of anti-CKII antibodies may be of value for differential diagnosis.

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Accession: 008169939

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PMID: 8252720


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