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Antihypertensive activity of a nonpeptide angiotensin II receptor antagonist, YM358, in rats and dogs

, : Antihypertensive activity of a nonpeptide angiotensin II receptor antagonist, YM358, in rats and dogs. European Journal Of Pharmacology. 335(2-3): 175-184

The antihypertensive activity of YM358, 2,7-diethyl-5-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5H-pyrazolo(1,5-b)(1,2,4)triazole potassium salt monohydrate, a new nonpeptide angiotensin II receptor antagonist, was characterized in rats and dogs. In conscious rats, YM358 after a single oral administration (1-30 mg/kg) lowered blood pressure. The rank order of hypotensive potency of YM358 in conscious rats was 2-kidney, 1-clip renal hypertensive rats gt spontaneously hypertensive rats gt normotensive rats on the basis of maximum hypotension. YM358 also caused decreases in blood pressure in 2-kidney, 1-clip renal hypertensive dogs and furosemide-treated dogs. Repeated administration of YM358 to 2-kidney, 1-clip renal hypertensive rats for 28 days produced a stable and long-lasting antihypertensive effect without influencing circadian blood pressure and heart rate rhythms. No reflex tachycardia was observed in any animals of either species treated with YM358. Therefore, the pharmacological profile of this compound indicates that YM358 has potential as a useful antihypertensive agent.

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Accession: 008173051

DOI: 10.1016/s0014-2999(97)01190-4

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Strakova J.; Dvorak M.; Kolouch F.; Nastuneak J.; Janeckova L.; Vanova L.; Volf B.; Picmausova D., 1990: Preparation containing calcium phosphorus magnesium and glucose toxicity and tolerance. The parenteral solution containing 16.8 mg calcium, 4.6 mg phosphorus, 3.76 mg magnesium and 160 mg glucose per 1 ml, given the name Capemag inj., was technologically developed by the Biotika Corporation at Slovenska Lupca and was tested at the Re...

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Stein, K.M.; Leyden, J.J.; Goldschmidt, H., 1972: Localized acneiform eruption following cobalt irradiation. British Journal of Dermatology 87(3): 274-279

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Stankiewicz, A., 2012: Age-related macular degeneration (AMD)--primary results "Bus-Tour'2011" action. The aim of article is to sum up "Bus-Tour'2011" action concerning age-related macular degeneration (AMD). Between March 29 to May 28.2011 in 10 polish cities 7292 persons were examined. The ophthalmological examination were done in...

Kisiel, W.; Fujikawa, K., 1983: Enzymological aspects of blood coagulation. Recent studies on the mechanism of initiation and regulation of blood coagulation are reviewed. In the intrinsic blood coagulation pathway, factor XII, prekallikrein (or factor XI) and high molecular weight kininogen from a complex on an anionic s...

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