EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Antihypertensive activity of a nonpeptide angiotensin II receptor antagonist, YM358, in rats and dogs



Antihypertensive activity of a nonpeptide angiotensin II receptor antagonist, YM358, in rats and dogs



European Journal Of Pharmacology. 335(2-3): 175-184



The antihypertensive activity of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a new nonpeptide angiotensin II receptor antagonist, was characterized in rats and dogs. In conscious rats, YM358 after a single oral administration (1-30 mg/kg) lowered blood pressure. The rank order of hypotensive potency of YM358 in conscious rats was 2-kidney, 1-clip renal hypertensive rats > spontaneously hypertensive rats > normotensive rats on the basis of maximum hypotension. YM358 also caused decreases in blood pressure in 2-kidney, 1-clip renal hypertensive dogs and furosemide-treated dogs. Repeated administration of YM358 to 2-kidney, 1-clip renal hypertensive rats for 28 days produced a stable and long-lasting antihypertensive effect without influencing circadian blood pressure and heart rate rhythms. No reflex tachycardia was observed in any animals of either species treated with YM358. Therefore, the pharmacological profile of this compound indicates that YM358 has potential as a useful antihypertensive agent.

Accession: 008173051

Download citation: RISBibTeXText

PMID: 9369371

DOI: 10.1016/s0014-2999(97)01190-4

Download PDF Full Text: Antihypertensive activity of a nonpeptide angiotensin II receptor antagonist, YM358, in rats and dogs



Related references

Antihypertensive effects of YM358, a novel angiotensin II receptor antagonist, in rats with one-kidney, one clip hypertension. Japanese Journal of Pharmacology 64(SUPPL 1): 83P, 1994

Pharmacological profile of YM358, a novel nonpeptide angiotensin AT-1 receptor antagonist. European Journal Of Pharmacology. 335(2-3): 167-173, 1997

Antihypertensive effect of repeatedly administered YM358, an angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats. Japanese Journal of Pharmacology 73(1): 83-91, 1997

Antihypertensive effects of YM358, a novel angiotensin II receptor antagonist. Japanese Journal of Pharmacology 61(SUPPL 1): 212P, 1993

Antihypertensive mechanism of captopril in renal hypertensive rats: studies with a nonpeptide angiotensin II receptor antagonist and an angiotensin II monoclonal antibody. Journal of Pharmacology and Experimental Therapeutics 250(2): 515-522, 1989

In vivo pharmacology and antihypertensive activity of L-159,282 a nonpeptide angiotensin II receptor antagonist. American Journal of Hypertension 7(4 PART 2): 54A, 1994

Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs. Naunyn-Schmiedeberg's Archives of Pharmacology 345(6): 673-678, 1992

Antihypertensive activity of the non peptide angiotensin ii receptor antagonist skf 108566 in rats and dogs. Naunyn-Schmiedeberg's Archives of Pharmacology 345(6): 673-678, 1992

Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent. Journal of Pharmacology and Experimental Therapeutics 252(2): 726-732, 1990

Antihypertensive activity and pharmacokinetics of KD3-671, a nonpeptide AT1-receptor antagonist, in renal hypertensive dogs. Journal of Cardiovascular Pharmacology 32(5): 834-844, 1998

Antihypertensive effect of SC-52458, a novel nonpeptide angiotensin II receptor antagonist, in freely moving experimental hypertensive rats. Japanese Journal of Pharmacology 64(SUPPL 1): 340P, 1994

Antihypertensive effect of chronic KT3-671, a structurally new nonpeptide angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats. Japanese Journal of Pharmacology 69(3): 215-222, 1995

Comparative inhibitory effects of an angiotensin ii aii monoclonal antibody and a nonpeptide aii receptor antagonist on the antihypertensive effect of captopril in renal hypertensive rats. FASEB Journal 3(3): A692, 1989