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Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies



Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies



Fertility and Sterility 66(4): 540-546



Objective: To describe the prevalence of antiphospholipid antibodies in addition to cardiolipin in women with recurrent pregnancy loss. Design: Retrospective data analysis of test results from an antiphospholipid antibody panel. Setting: A university-based private patient referral center. Patients: Included 866 women with a history of recurrent pregnancy loss and 288 parous women without a history of reproductive problems. Interventions: None. Main Outcome Measures: Enzyme-linked immunosorbent assay, with referenced standards and known positive and negative sera on each plate, was used to measure anticardiolipin, antiphosphatidylinositol, antiphosphatidylglycerol, antiphosphatidylserine, and antiphosphatidylethanolamine. Statistical analyses used the two-tailed Fisher's exact test. Results: Positive anticardiolipin antibodies were detected in 17.3% of patients with recurrent pregnancy loss compared with only 4% in the control population. Eighty-seven of the 866 women (10.1%) were negative for anticardiolipin antibodies but had positive levels of another antiphospholipid antibody. Isolated positive antibody levels occurred most frequently in the immunoglobulin (Ig) G class of phosphatidylinositol, cardiolipin, and phosphatidylethanolamine. Isolated IgA was only found in phosphatidylethanolamine. Conclusion: In women with recurrent pregnancy loss, 150 of 866 (17.3%) had positive anticardiolipin antibodies. Additionally, 87 of 866 (10.1%) women were positive for another antiphospholipid antibody. Patient demographics were similar in both groups. We emphasize the importance of careful standardization, quality control, and interpretation of positive results.

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Accession: 008175507

Download citation: RISBibTeXText

PMID: 8816614

DOI: 10.1016/s0015-0282(16)58565-3


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