Application of vicarious nucleophilic substitution in organic synthesis

Makosza, M.; Wojciechowski, K.

Liebigs Annalen-Recueil. 1997(9): 1805-1816

1997


DOI: 10.1002/jlac.199719970903
Accession: 008183457

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Abstract
Vicarious Nucleophilic Substitution (VNS) provides the possibility of the replacement of hydrogen atoms in electrophilic arenes with alpha-functionalized alkyl substituents. This review focuses on the transformations of products obtained by VNS, particularly into heterocyclic compounds. In addition, some characteristic features of the VNS mechanism are briefly described.

Application of vicarious nucleophilic substitution in organic synthesis