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Assessment of the significance of virulence factors of uropathogenic Escherichia coli in experimental urinary tract infection in mice



Assessment of the significance of virulence factors of uropathogenic Escherichia coli in experimental urinary tract infection in mice



Microbiology and Immunology 40(9): 607-610



Four Escherichia coli strains, isolated from cystitis patients, belonging to serotype O2:H- and possessing different combinations of urovirulence factors were examined in an experimental pyelonephritis mouse model to assess the relative importance of virulence factors in causation of urinary tract infections (UTI). The results suggest not only that the each virulence factor has a role in causation of UTI but also that the presence of P fimbriae and production of hemolysin significantly reduced the LD-50 and ID-50 of the strains in the mouse model. The results also demonstrate that the presence of additional virulence factors acts in an additive or synergetic fashion enhancing the cumulative impact of the strain.

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Accession: 008194941

Download citation: RISBibTeXText

PMID: 8908603

DOI: 10.1111/j.1348-0421.1996.tb01116.x


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