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Asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acid derivatives using MABR promoted rearrangement



Asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acid derivatives using MABR promoted rearrangement



Tetrahedron Letters 39(22): 3749-3752



An efficient route for the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement.

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