Augmented expression of the endothelin-A receptor gene in cultured mesangial cells from stroke-prone spontaneously hypertensive rats

Hiraoka, J.; Arai, H.; Yoshimasa, T.; Takaya, K.; Miyamoto, Y.; Yamashita, J.; Suga, S.; Ogawa, Y.; Shirakami, G.; Itoh, H.

Clinical and Experimental Pharmacology and Physiology. Supplement 22(1): S191-S192

1995


ISSN/ISBN: 0143-9294
PMID: 9072350
DOI: 10.1111/j.1440-1681.1995.tb02876.x
Accession: 008203548

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Abstract
1. To elucidate the role of endothelin (ET) receptor in hypertension, we studied the expression of the ET-A receptor (ET-AR) gene and the ET-B receptor (ET-BR) gene in cultured mesangial cells isolated from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats. 2. The mesangial cells from both SHRSP and WKY expressed ET-AR predominantly. The level of the ET-AR mRNA in mesangial cells from SHRSP was 5-fold higher than that in the cells from WKY. The ET-BR mRNA in the mesangial cells from both strains was hardly detectable by northern blot analysis. 3. These results demonstrate that the expression of the ET-AR gene was markedly augmented in mesangial cells from SHRSP.

Augmented expression of the endothelin-A receptor gene in cultured mesangial cells from stroke-prone spontaneously hypertensive rats