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Bactericidal action of gentamicin against enterococci that are sensitive, or exhibit low- or high-level resistance to gentamicin



Bactericidal action of gentamicin against enterococci that are sensitive, or exhibit low- or high-level resistance to gentamicin



Diagnostic Microbiology & Infectious Disease. : 57-60



Treatment of serious enterococcal infection involves the use of penicillin-aminoglycoside combination therapy if the aminoglycoside minimum inhibitory concentration (MIC) is ltoreq 200 mu-g/ml, and the organism is susceptible to penicillin or ampicillin. We evaluated killing of 15 enterococci that differ in their susceptibility to gentamicin using time-kill studies at different gentamicin concentrations. Sensitive strains had a uniform population killed by gentamicin concentrations equal to or above the MIC. Low-level resistant strains (MIC gtoreq 8 but ltoreq 2000 mu-g/ml of gentamicin) had a diverse population with large numbers of cells killed at one-half the MIC, while the highly resistant strains (MIC gt 2000 mu-g/ml) showed no killing by any concentration of gentamicin.

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Accession: 008211702

Download citation: RISBibTeXText

PMID: 7956015

DOI: 10.1016/0732-8893(94)90052-3


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