EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Basaloid squamous carcinoma of the head and neck: Immunohistochemical comparison with adenoid cystic carcinoma and squamous cell carcinoma



Basaloid squamous carcinoma of the head and neck: Immunohistochemical comparison with adenoid cystic carcinoma and squamous cell carcinoma



Archives of Otolaryngology Head and Neck Surgery 119(8): 887-890



Basaloid squamous carcinoma (BSC) is a rare distinct variant of squamous cell carcinoma of the head and neck region. This entity may commonly pose diagnostic difficulties, especially on small biopsy material. We report the clinicopathological characteristics of 12 new cases and compare their immunohistochemical features with those of solid adenoid cystic carcinomas and conventional squamous cell carcinomas. Our results show that neoplastic BSCs and squamous cell carcinomas do not react to vimentin and S100 protein, while adenoid cystic carcinomas manifest both. The BSCs, however, are S100 protein-positive in intratumoral dendritic Langerhans' cells that are lacking in squamous cell and adenoid cystic carcinomas. Our findings indicate that the immunohistochemical differences between BSC and adenoid cystic carcinoma could assist in their differential diagnosis.

(PDF emailed within 0-6 h: $19.90)

Accession: 008213615

Download citation: RISBibTeXText

PMID: 8393682

DOI: 10.1001/archotol.1993.01880200093013



Related references

Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid carcinoma in the upper aerodigestive tract. Anticancer Research 20(2b): 1205-1211, 2000

Primary combined adenoid cystic carcinoma, basaloid squamous cell carcinoma, and squamous cell carcinoma of the esophagus. Endoscopy 44 Suppl 2 Uctn: E102-E103, 2012

A Limited Immunohistochemical Panel to Distinguish Basal Cell Carcinoma of Cutaneous Origin From Basaloid Squamous Cell Carcinoma of the Head and Neck. Applied Immunohistochemistry & Molecular Morphology 26(2): 126-131, 2016

Adenoid cystic carcinoma of the palate with squamous metaplasia or basaloid-squamous carcinoma? Report of a case. Journal Of Oral Pathology & Medicine. 23(10): 461-464, 1994

Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck. Head & Neck 29(5): 472-478, 2006

p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Modern Pathology 18(5): 645-650, 2004

Distinction of basaloid squamous carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. Laboratory Investigation 76(1): 116A, 1997

Basaloid squamous cell carcinoma of the head and neck A heterogeneous group with different cytokeratin immunoprofiles from conventional squamous cell carcinoma. European Journal of Cancer Supplements 6(9): 157-158, 2008

Basaloid Squamous Cell Carcinoma: An Aggressive Variant of Squamous Cell Carcinoma of the Head and Neck Region. Pathology Case Reviews 5(4): 200-205, 2000

Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. Human Pathology. 29(6): 609-612, E, 1998

Basaloid squamous cell carcinoma of head and neck Clinicopathologic and immunohistochemical study of 10 cases. Virchows Archiv 435(3): 174, Sept, 1999

Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases. American Journal of Surgical Pathology 16(10): 939-946, 1992

Basaloid squamous cell carcinoma bscc of the head and neck a clinicopathologic and immunohistochemical study of 39 cases. Laboratory Investigation 64(1): 63A, 1991

Ultrastructural distinction of basaloid-squamous carcinoma and adenoid cystic carcinoma. Ultrastructural Pathology 19(5): 371-381, 1995

Basaloid squamous carcinoma of the upper aerodigestive tract and so called adenoid cystic carcinoma of the esophagus the same tumor type. Histopathology (Oxford) 19(1): 35-46, 1991