+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene



Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene



Bioorganic and Medicinal Chemistry Letters 6(7): 903-908



Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and serum lipid parameters. A structural model that accounts for the pharmacological similarity of these benzopyrans and the benzothiophene SERM, raloxifene, is proposed.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008219116

Download citation: RISBibTeXText

DOI: 10.1016/0960-894x(96)00141-2


Related references

The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen improve ANP levels and decrease nuclear translocation of NF-kB in estrogen-deficient rats. Pharmacological Reports 69(4): 798-805, 2017

Acquired resistance to selective estrogen receptor modulators (SERMs) in clinical practice (tamoxifen & raloxifene) by selection pressure in breast cancer cell populations. Steroids 90: 44-52, 2015

Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro. British Journal of Pharmacology 151(3): 384-395, 2007

The role of activation functions 1 and 2 of estrogen receptor-a for the effects of estradiol and Selective Estrogen Receptor Modulators SERMs in male mice. 2013

Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors. Molecular Genetics and Metabolism 76(3): 225-233, 2002

Selective estrogen receptor modulators (SERMs): effects on multiple organ systems. Current Medicinal Chemistry 7(5): 577-584, 2000

Selective Estrogen Receptor Modulators (Serms): Effects on Multiple Organ Systems. Current Medicinal Chemistry 7(5): 577-584, 2000

Effects of SERMs on bone health. Evidence for the selective estrogen receptor modulator raloxifene: its evolving role in the treatment of osteoporosis. Clinical Calcium 20(3): 315-321, 2010

Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment. Pharmacology and Therapeutics 186: 1-24, 2018

The differential effects of bisphosphonates, SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone remodeling in osteoporosis. Clinical Interventions in Aging 2(1): 55-64, 2007

Selective estrogen receptor modulators (SERMs). Clinical Calcium 16(9): 1520-1525, 2006

Selective estrogen receptor modulators (SERMs). Current Pharmaceutical Design 4(1): 71-92, 1999

Selective estrogen receptor modulators (SERMS). Arquivos Brasileiros de Endocrinologia E Metabologia 50(4): 720-734, 2006

Bioactivation of Selective Estrogen Receptor Modulators (SERMs). Chemical Research in Toxicology 19(9): 1125-1137, 2006

New selective estrogen receptor modulators (SERMs) in development. Current Osteoporosis Reports 8(3): 151-153, 2010