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Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM



Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM



Journal of Neuroimmunology 48(1): 81-90



The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturally occurring neuropeptide, beta-endorphin, reduced the incidence of JHMV-induced paralytic-demyelinating disease 40-50% in C57Bl/6 mice. Protection from disease was accompanied by significantly reduced virus replication in the brain as early as 3 days post-infection and did not occur in irradiated, or immunoincompetent mice. The data suggest that beta-endorphin engages immune mechanisms of host resistance to JHMV infection to protect the mice from disease.

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Accession: 008220059

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PMID: 8227310


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