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Beta-endorphin-induced cardiorespiratory depression is inhibited by glycyl-L-glutamine, a dipeptide derived from beta-endorphin processing



Beta-endorphin-induced cardiorespiratory depression is inhibited by glycyl-L-glutamine, a dipeptide derived from beta-endorphin processing



Journal of Pharmacology and Experimental Therapeutics 271(2): 952-958



Glycyl-L-glutamine (Gly-L-Gln), or beta-endorphin-(30-31) [beta-End-(30-31)], is synthesized through the post-translational processing of beta-End-(1-31). Evidence that gly-L-gln is a prominent end product of beta-End-(1-31) processing in cardioregulatory regions of rat brain prompted us to investigate whether it modulates the cardiorespiratory depression induced by central beta-End-(1-31) injection. As shown previously, beta-End-(1-31) (0.5 nmol) lowered mean arterial pressure (MAP) and HR when administered i.c.v. to pentobarbital-anesthetized rats. Gly-L-gln (0.3, 0.6, 1.0 and 10.0 nmol) produced a dose-related inhibition of beta-End-(1-31)-induced hypotension, but not bradycardia, when injected i.c.v. 15 min after beta-End-(1-31). This effect was not attributable to hydrolysis, because equimolar amounts of L-glycine and L-glutamine were ineffective. A comparable response was observed when gly-L-gln was administered to urethane-anesthetized rats and when it was injected before beta-End-(1-31). Gly-L-gln also attenuated the respiratory depressant effect of beta-End-(1-31), significantly inhibiting beta-End-(1-31)-induced hypoxia and hypercapnia. Gly-L-gln (1, 10 and 100 nmol) was inactive when injected alone, however, and produced no significant variation from base-line MAP or HR values. These results demonstrate that gly-L-gln inhibits beta-End-(1-31)-induced cardiorespiratory depression, consistent with accumulating evidence that gly-L-gln functions as a neuromodulator.

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Accession: 008220066

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PMID: 7965817


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