Section 9
Chapter 8,224

Binding of eukaryotic translation initiation factor 4E (eIF4E) to eIF4G represses translation of uncapped mRNA

Tarun, S.Z.; Sachs, A.B.

Molecular and Cellular Biology 17(12): 6876-6886


ISSN/ISBN: 0270-7306
PMID: 9372919
DOI: 10.1128/mcb.17.12.6876
Accession: 008223593

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mRNA translation in crude extracts from the yeast Saccharomyces cerevisiae is stimulated by the cap structure and the poly(A) tail through the binding of the cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) and the poly(A) tail-binding protein Pab1p. These proteins also bind to the translation initiation factor eIF4G and thereby link the mRNA to the general translational apparatus.

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