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Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats

Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats

Pharmacology Biochemistry and Behavior 45(1): 89-93

In a three-panel runway task, intrahippocampal injection of the nicotinic receptor antagonist, mecamylamine (10 and 18 mu-g/side), significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in a test of working memory. This increase in errors also occurred after rats were given IP mecamylamine (10 mg/kg). Mecamylamine did not affect the number of errors in a test of reference memory whether it was given at doses up to 18 mu-g/side intrahippocampally or up to 10 mg/kg IP. These results suggest that mechanisms mediated by hippocampal nicotinic receptors play a role in working memory but not in reference memory.

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Accession: 008236591

Download citation: RISBibTeXText

PMID: 8516378

DOI: 10.1016/0091-3057(93)90091-7

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