+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Bone marrow plays a role in bone metabolism: Histomorphometry of iliac bone in postmenopausal women

Bone marrow plays a role in bone metabolism: Histomorphometry of iliac bone in postmenopausal women

Calcified Tissue International 51(5): 348-351

We conducted a histomorphometrical study on the role of the bone marrow in cancellous bone metabolism using iliac bone specimens from 79 postmenopausal women. A gradual decrease in hematopoietic tissue of the bone marrow was proportionate to the decrease in cancellous bone and the ratio of osteoid perimeter/bone perimeter regardless of age. On the other hand, the ratio of eroded perimeter/bone perimeter remained almost steady until hematopoietic tissue decreased significantly. These findings suggest that a change in the bone marrow, that is, a decrease in hematopoietic tissue, causes as imbalance in bone formation and resorption and leads to bone loss.

(PDF emailed within 0-6 h: $19.90)

Accession: 008240137

Download citation: RISBibTeXText

PMID: 1458338

DOI: 10.1007/bf00316878

Related references

Concentration of insulin-like growth factor (IGF)-I and -II in iliac crest bone matrix from pre- and postmenopausal women: relationship to age, menopause, bone turnover, bone volume, and circulating IGFs. Journal of Clinical Endocrinology and Metabolism 83(7): 2331-2337, 1998

Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?. Journal of Clinical Endocrinology and Metabolism 100(12): 4662-4668, 2016

IL-1-beta and IL-1RA gene expression in transiliac bone biopsies Correlation with bone loss and histomorphometry in healthy postmenopausal women. Bone (New York) 19(3 SUPPL ): 130S, 1996

Morphological analysis of bone dynamics and metabolic bone disease. Bone histomorphometry : the basic methods and role of bone research and clinical significance. Clinical Calcium 21(4): 529-533, 2011

Bone metabolism in postmenopausal women with lumbar spinal stenosis: analysis of bone mineral density and bone turnover markers. Spine 33(22): 2435-2439, 2008

Commencing, continuing and stopping brisk walking: effects on bone mineral density, quantitative ultrasound of bone and markers of bone metabolism in postmenopausal women. Osteoporosis International 12(7): 581-587, 2001

Association of bone metabolism related genes polymorphisms with the effect of raloxifene hydrochloride on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23(2): 129-133, 2006

Study of bone mass and biochemical parameters of bone metabolism in young women after bone marrow transplantation. Arthritis & Rheumatism 39(9 SUPPL ): S140, 1996

Effect of risedronate on osteocyte viability and bone turnover in paired iliac bone biopsies from early postmenopausal women. Calcified Tissue International 87(5): 392-397, 2011

Effect of 17beta-estradiol or alendronate on the bone densitometry, bone histomorphometry and bone metabolism of ovariectomized rats. Brazilian Journal of Medical and Biological Research 34(8): 1015-1022, 2001

The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. Journal of Clinical Investigation 92(6): 2577-2586, 1993

Bone marrow cell number plays but gvhr induced immunosuppression does not play a role in preventing graft rejection after allogeneic bone marrow transplantation bmt. Immunobiology 181(2-3): 248-249, 1990

Assessment of porcine bone metabolism by F18-Fluoride ion PET Correlation between compartment modeling, Patlak plot and SUV analysis with bone histomorphometry in normal and high-turnover bone. Journal of Nuclear Medicine 44(5 Supplement): 97P, 2003

The establishment of an in vivo assay system of bone metabolism using lengthened callus and dual energy X-ray absorptiometry: Age-related decline of bone formation, enhancement by the bone marrow cell transplantation and inhibition of bone formation by bone marrow cell lysate. Medical Journal of Kinki University 19(1): 73-91, 1994

Relationships between static histomorphometry and bone strength measurements in human iliac crest bone biopsies. Bone (New York) 22(2): 153-163, 1998