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Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs


Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs



Neuroscience Letters 150(1): 25-28



ISSN/ISBN: 0304-3940

PMID: 8469398

DOI: 10.1016/0304-3940(93)90099-7

We have investigated the effects of antipsychotic drugs on the expression of the two dopamine D-2 receptor splicing variants using multiprobe oligonucleotide solution hybridisation. Both long and short mRNA variants were increased in abundance by approximately 2-fold by both haloperidol and loxapine after 32 days drug administration.

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Accession: 008241536

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