Section 9
Chapter 8,248

Bunazosin enhances receptor-mediated endocytosis of low-density lipoproteins

Matsunaga, A.; Hidaka, K.; Sasaki, J.; Arakawa, K.

Artery 19(6): 307-317


ISSN/ISBN: 0098-6127
PMID: 1361724
Accession: 008247982

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The effects of bunazosin, an alpha-1-adrenergic receptor antagonist, on low-density lipoprotein (LDL) receptor activity have been studied in cultured cells. Human skin fibroblasts, swine aortic smooth muscle cells and a human hepatoma cell line (Hep G2) were used for this study. Bunazosinm, at a concentration of 5 times 10-5 to 10-4 M, increased 125I-LDL uptake with all of the cell lines and 125I-LDL degradation with human skin fibroblasts and swine aortic smooth muscle cells. However, in human skin fibroblasts pretreated with lipoprotein deficient serum and Hep G2 cells, the degradation of 125I-LDL was decreased by bunazosin. These results suggest that bunazosin increases LDL receptor activity.

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