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Ca2+ and contractile responses of resistance vessels of WKY rats and SHR to endothelin-1

Ca2+ and contractile responses of resistance vessels of WKY rats and SHR to endothelin-1

Journal of Cardiovascular Pharmacology 26(Suppl. 3): S193-S196

Endothelin-1 (ET-1) influences vascular function by modulating intracellular free Ca-2+ concentration ((Ca-2+)-i) in smooth muscle. This study investigated the effects of ET-1 on (Ca-2+)-i and contractile responses in resistance vessels of young prehypertensive (5 week) and adult hypertensive (17 week) spontaneously hypertensive rats (SHRs) and in age-matched normotensive Wistar-Kyoto (WKY) rats. Third-order branches of mesenteric arteries were mounted in a perfusion myograph and maintained at 60 mm Hg. Vessel (Ca-2+)-i was measured by Fura-2 and contraction was determined using video imaging to record lumen diameter. (Ca-2+)-i was higher (p lt 0.01) in 5- and 17-week SHRs compared with 5- and 17-week WKYs rats. ET-1 increased (Ca-2+)-i and contractile responses in a dose-dependent manner in all groups. ET-induced (Ca-2+)-i change and vessel contractility were not significantly different between age-matched SHR and WKY groups, but (Ca-2+)-i responses were more sensitive in 5- compared with 17-week SHRs. These data demonstrate that ET-1-stimulated (Ca-2+)-i and contractile responses in resistance arteries are similar in age-matched WKY rats and SHRs and are blunted in adult SHRs compared with young prehypertensive rats. Therefore, ET-1 may not play a major role in the development of hypertension in SHRs.

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Accession: 008253637

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PMID: 8587360

DOI: 10.1097/00005344-199526003-00058

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