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Cardiovascular effects of microinjection of dynorphin fragments into the nucleus of the solitary tract (NTS) are mediated by non-opioid mechanisms



Cardiovascular effects of microinjection of dynorphin fragments into the nucleus of the solitary tract (NTS) are mediated by non-opioid mechanisms



Brain Research 623(1): 110-116



The nucleus of the solitary tract (NTS) is important for the regulation of cardiovascular homeostasis. In the present study we investigated the effect of dynorphin A-(1-13), dynorphin A-(1-17) and dynorphin A-(2-17) microinjected into the NTS on mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), stroke volume (SV) and left ventricular stroke work (LVSW) following hemorrhage in conscious rats. Following fixed-volume hemorrhage (8 ml/300 g), microinjection of dynorphin A-(2-17) (6 nmol), which is inactive at opioid receptors, into the NTS significantly attenuated the recovery of CO, SV and LVSW following hemorrhage when compared to those animals receiving a microinjection of normal saline (NS) vehicle into the NTS (P < 0.01). NTS microinjection of dynorphin A-(2-17) also increased HR following hemorrhage when compared with the NS group (P < 0.05). No significant effects were observed on CO, SV and LVSW following NTS microinjection of the kappa-opioid agonists, dynorphin A-(1-13) and dynorphin A-(1-17), although dynorphin A-(1-13) microinjection increased HR following hemorrhage when compared with control animals (P < 0.05). Microinjection of all three peptide fragments had no significant effect on MAP when compared with MAP of the control group following hemorrhage. The results of this study suggest that dynorphin A-(2-17) in the NTS can attenuate the compensatory cardiovascular responses to hemorrhage, perhaps via a non-opioid mechanism.

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Accession: 008266988

Download citation: RISBibTeXText

PMID: 8106118

DOI: 10.1016/0006-8993(93)90017-h



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