+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Catalepsy induced by calcium channel blockers in mice



Catalepsy induced by calcium channel blockers in mice



Biopharmaceutics & Drug Disposition. : 115-122, Ch



It is known that calcium channel blockers induce Parkinsonism. In this study, amlodipine-, diltiazem-, and verapamil-induced catalepsy was investigated in mice. All of these three calcium channel blockers induced catalepsy. Dopamine D1, D2, and mACh receptor occupancies were estimated under the same conditions, and the affinities of these drugs for each receptor were also estimated in vitro. Intensity of catalepsy was predicted by dopamine D1, D2, and mACh receptor occupancies with the dynamic model which had already been constructed and was compared with the observed values. The predicted and the observed values were comparable (r = 0.98, p < 0.001). In conclusion, the dynamic model considering D1, and D2, and mACh receptor occupancy may be useful for quantitative prediction of drug-induced catalepsy.

(PDF emailed within 0-6 h: $19.90)

Accession: 008269771

Download citation: RISBibTeXText

PMID: 9533112

DOI: 10.1002/(sici)1099-081x(199803)19:2<115::aid-bdd86>3.0.co;2-q


Related references

Evidence of sex related differences in the effects of calcium channel blockers on neuroleptic-induced catalepsy in mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry 23(2): 301-316, 1999

Gender-related differences in the effects of calcium channel blockers on neuroleptic-induced catalepsy. Society for Neuroscience Abstracts 23(1-2): 412, 1997

Catalepsy induced by manidipine, a calcium channel blocker, in mice. Journal Of Pharmacy & Pharmacology. 48(4): 429-432, 1996

Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L calcium channel in DBA/2 mice. General Pharmacology. 23(6): 1205-1216, 1992

Combination of calcium channel blockers and beta-blockers for patients with exercise-induced angina pectoris: beneficial effect of calcium channel blockers largely determined by their effect on heart rate. Journal of Clinical Pharmacology 39(7): 738-746, 1999

Combination of calcium channel blockers and beta blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. The Netherlands Working Group on Cardiovascular Research (WCN). Angiology 50(6): 447-454, 1999

Combination of calcium channel blockers and beta-adrenoceptor blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. Netherlands Working Group on Cardiovascular Research (WCN). British Journal of Clinical Pharmacology 47(5): 493-498, 1999

Effect of pre-treatment of some calcium channel blockers on catalepsy and stereotypic behaviour in rats. Indian Journal of Physiology and Pharmacology 40(2): 159-162, 1996

Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons. Diabetologia 44(10): 1302-1309, 2001

Os 31-04 Comparison Of Calcium Channel Blockers Versus Calcium Channel Blockers With Renin Angiotensin System Blockers On The Development Of New-Onset Diabetes Mellitus In Hypertensive Patients. Journal of Hypertension 34 Suppl 1 - Ish 2016 Abstract Book(): E388-E389, 2016

Effects of intrathecally administered aminoglycoside antibiotics, calcium-channel blockers, nickel and calcium on acetic acid-induced writhing test in mice. General Pharmacology. 30(4): 613-616, Il, 1998

L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta Pharmacologica Sinica 25(5): 644-650, 2004

The effect of calcium channel blockers calcium blockers on the ethanol eth induced microvascular injury of the jejunal mucosa. Gastroenterology 98(5 PART 2): A184, 1990

Influence of calcium channel blockers on pentylenetetrazole and electroshock induced convulsions in mice. Polish Journal of Pharmacology & Pharmacy 43(2): 95-102, 1991