+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm

Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm

Archives of Otolaryngology--Head & Neck Surgery 120(11): 1273-1276

A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008283593

Download citation: RISBibTeXText

PMID: 7917213

DOI: 10.1001/archotol.1994.01880350079014

Related references

Malignant transformation of recurrent respiratory papillomatosis associated with integrated human papillomavirus type 11 DNA and mutation of p53. Laryngoscope 108(5): 735-740, 1998

Malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. American Journal of Otolaryngology 31(4): 291-296, 2010

Rare case of malignant transformation of recurrent respiratory papillomatosis associated with human papillomavirus type 6 infection and p53 overexpression. Springerplus 2(1): 153, 2013

Natural History and Malignant Transformation in Recurrent Respiratory Papillomatosis: Human Papillomavirus (HPV), Dysplasia and an Autopsy Review. Fetal and Pediatric Pathology 34(2): 80-90, 2015

Clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. Head and Neck 37(11): 1625-1632, 2015

Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease. Pediatric and Developmental Pathology 4(1): 68-72, 2001

Detection of human papillomavirus in the upper respiratory tract in children without recurrent respiratory papillomatosis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47(12): 974-977, 2012

Detection of human papillomavirus infection in diseased and nondiseased sites of the respiratory tract in recurrent respiratory papillomatosis patients by DNA hybridization. Annals of Otology Rhinology and Laryngology 101(5): 408-412, 1992

Human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction. Archives of Otolaryngology--Head & Neck Surgery 119(5): 554-557, 1993

Molecular identification of 7 human papillomavirus types in recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 126(9): 1119-1123, 2000

The heterogeneous distribution of human papillomavirus activities in recurrent respiratory papillomatosis. Journal of Investigative Medicine 43(Suppl. 1): 1A, 1995

Detection and cloning of human papillomavirus DNA associated with recurrent respiratory papillomatosis in Thailand. Japanese Journal Of Cancer Research. 85(7): 699-703, 1994

Divergent human papillomavirus associated with recurrent respiratory papillomatosis with lung involvement. Genome Announcements 1(4):, 2013

Human papillomavirus genotype detection in recurrent respiratory papillomatosis (RRP) in Colombia. Head and Neck 35(2): 229-234, 2013