Changes in the E/A ratio induced by handgrip-exercise are related to changes in the plasma atrial natriuretic peptide level, but not to changes in brain natriuretic peptide in mild essential hypertension

Tomiyama, H.; Kushiro, T.; Imai, S.; Suzuki, Y.; Akutsu, N.; Ebuchi, T.; Iida, T.; Murai, I.; Nakagawa, S.; Kajiwara, N.

Japanese Circulation Journal 59(9): 617-623


ISSN/ISBN: 0047-1828
PMID: 7500545
DOI: 10.1253/jcj.59.617
Accession: 008285766

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We investigated the relationship between changes in atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) and changes in cardiac function during mild exercise in patients with mild hypertension. The handgrip test (HGT) was performed by 21 untreated, mildly hypertensive patients, mean age 45 +- 5 years. M-mode and pulse Doppler echocardiograms were recorded before and during HGT. In 7 patients (Group A), diastolic function, which was determined by the peak early velocity and peak atrial velocity (E/A) ratio using Doppler echocardiography was attenuated during HGT (1.19 +- 0.21 to 1.04 +- 0.16, p lt 0.05). There was no change in diastolic function in the remaining 14 patients (Group B) (1. 04 +- 0.19 to 1.03 +- 0.18, NS). Neither left ventricular mass index, left atrial diameter, cardiac index, ejection fraction, plasma renin activity, plasma norepinephrine, blood pressure, nor heart rate were different between the two groups. While ANP was increased in Group A during HGT (from 41.0 +- 18.2 to 54.0 +- 24.1 pg/ml, p lt 0.05) it was unchanged in Group B (36.8 +- 16.3 to 33.5 +- 11.9 pg/ml). BNP did not change in either Group (Group A: 2.9 +- 3.1 to 3.0 +- 3.4 pg/ml, Group B: 2.6 +- 1.6 to 3.6 +- 4.8 pg/ml). The percent change in ANP during HGT did not correlate with the percent change in BNP. Thus, the impairment of cardiac functional reserve appeared to influence ANP excretion in patients with mild hypertension.