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Changes of plasma levels of human growth hormone with age in relation to mammary tumour appearance in whey acidic protein/human growth hormone (mWAP/hGH) transgenic female and male mice



Changes of plasma levels of human growth hormone with age in relation to mammary tumour appearance in whey acidic protein/human growth hormone (mWAP/hGH) transgenic female and male mice



In Vivo 10(5): 503-505



Plasma levels of human growth hormone (hGH) were determined in female and male transgenic mice with human growth hormone fusion gene driven by the promoter of mouse whey acidic protein (m WAP/hGH) at 3, 6 and 9 months of age and at mammary tumour appearance. In female transgenic mice developing mammary tumours, the plasma hGH level decreased markedly upon tumour appearance, which was associated with little change in body weight.

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Accession: 008287861

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PMID: 8899429


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